Bergmann I, Siepmann T, Kleinert P, Pescarmona G, Till U
Institute of Pathological Biochemistry, Medical Academy Erfurt, GDR.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):455-9.
The SH group containing drug MPG which inhibits platelet aggregation in a reversible manner was used as a cytoprotective substance in some experiments on preparation and storage of human platelets for transfusion. In vitro (n = 6): concentration, morphology score, HSR and aggregation of stored platelets were measured after simulating in vitro the post transfusional conditions by resuspension of stored platelets in fresh drawn plasma (pH 7.4, 37 degrees C). In vivo (n = 2): Autologous platelets stored for 48 h at 22 degrees C were labelled with 111In and retransfused. The results obtained from platelets prepared and stored in plasma containing MPG were compared with those obtained from control platelets without MPG.
含巯基药物MPG以可逆方式抑制血小板聚集，在一些关于人血小板制备和储存用于输血的实验中用作细胞保护物质。体外实验（n = 6）：通过将储存的血小板重悬于新鲜采集的血浆（pH 7.4，37℃）中模拟体外输血后条件，测定储存血小板的浓度、形态评分、高渗应激反应（HSR）和聚集情况。体内实验（n = 2）：将在22℃储存48小时的自体血小板用铟-111标记后重新输注。将在含MPG的血浆中制备和储存的血小板所获得的结果与不含MPG的对照血小板所获得的结果进行比较。
