Department of Pharmacology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, 431-31, Japan.
Platelets. 1993;4(5):280-4. doi: 10.3109/09537109309013229.
Time-dependent changes in platelet aggregation in whole blood, platelet-rich plasma (PRP) and washed platelets were studied in streptozotocin-induced diabetic rats. Collagen-induced aggregation of whole blood and PRP from diabetic rats were significantly reduced within 8 weeks after induction of diabetes, although that in washed platelets were increased from 8 weeks. Plasma from diabetic rats within 8 weeks attenuated platelet aggregation, whereas diabetic plasma at 12 weeks showed no inhibitory effect. Insulin treatment normalized aggregation in whole blood and PRP and abolished the antiaggregatory activity of diabetic plasma. These results suggest the plasma antiaggregating activity appears in the early stage of diabetes, which may contribute to the hypoaggregation in whole blood and PRP. The inhibitory activity disappeared in the later stage. Plasma factor(s) accounting for the antiaggregatory effect of diabetic plasma has not yet characterized.
研究了链脲佐菌素诱导的糖尿病大鼠全血、富含血小板的血浆（PRP）和洗涤血小板中血小板聚集的时间依赖性变化。糖尿病诱导后 8 周内，糖尿病大鼠全血和 PRP 诱导的胶原聚集明显减少，而洗涤血小板的聚集增加。8 周内糖尿病大鼠的血浆可减弱血小板聚集，而 12 周时糖尿病血浆则无抑制作用。胰岛素治疗可使全血和 PRP 的聚集正常化，并消除糖尿病血浆的抗聚集活性。这些结果表明，血浆抗聚集活性出现在糖尿病的早期阶段，这可能导致全血和 PRP 的低聚集。在后期，抑制活性消失。导致糖尿病血浆抗聚集作用的血浆因子尚未确定。
