Department of Neuroscience, Ohio State University, Columbus, Ohio 43210, USA.
J Neurochem. 2011 Jan;116(1):1-9. doi: 10.1111/j.1471-4159.2010.07080.x. Epub 2010 Dec 2.
Since its initial characterization over 20 years ago, there has been intense and unwavering interest in understanding the role of the transcription factor cAMP-responsive element binding protein (CREB) in nervous system physiology. Through an array of experimental approaches and model systems, researchers have begun to unravel the complex and multifaceted role of this transcription factor in such diverse processes as neurodevelopment, synaptic plasticity, and neuroprotection. Here we discuss current insights into the molecular mechanisms by which CREB couples synaptic activity to long-term changes in neuronal plasticity, which is thought to underlie learning and memory. We also discuss work showing that CREB is a critical component of the neuroprotective transcriptional network, and data indicating that CREB dysregulation contributes to an array of neuropathological conditions.
自 20 多年前首次被描述以来，人们一直对理解转录因子 cAMP 反应元件结合蛋白（CREB）在神经系统生理学中的作用有着浓厚而坚定的兴趣。通过一系列实验方法和模型系统，研究人员开始揭示这种转录因子在神经发育、突触可塑性和神经保护等多种过程中的复杂和多方面的作用。在这里，我们讨论了当前对 CREB 将突触活动与神经元可塑性的长期变化联系起来的分子机制的深入了解，人们认为这种联系是学习和记忆的基础。我们还讨论了表明 CREB 是神经保护转录网络的关键组成部分的工作，以及表明 CREB 失调导致一系列神经病理学状况的数据。
