Rheumazentrum Ruhrgebiet, Herne, Germany.
Clin Exp Rheumatol. 2010 Sep-Oct;28(5 Suppl 61):S164-7. Epub 2010 Oct 28.
The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been reported in myositis, it is difficult to make definitive recommendations for the treatment of these potentially life threatening diseases. In addition to treatment with corticosteroids, immunosuppressive agents and immunomodulatory therapy are used to improve disease control and reduce the long-term side effects of corticosteroids. While these treatments are commonly used in routine clinical practice, the optimal therapeutic regimen remains unclear. However, most patients with dermatomyositis or polymyositis are treated with oral high-dose prednisone combined with azathioprine or methotrexate to facilitate tapering of prednisone.
炎性肌病是一组异质性疾病，包括皮肌炎、多发性肌炎和包涵体肌炎。肌炎的临床试验报告较少，因此很难对这些潜在危及生命的疾病提出明确的治疗建议。除了皮质类固醇治疗外，还使用免疫抑制剂和免疫调节疗法来改善疾病控制并减少皮质类固醇的长期副作用。虽然这些治疗方法在常规临床实践中经常使用，但最佳治疗方案仍不清楚。然而，大多数皮肌炎或多发性肌炎患者接受口服大剂量泼尼松龙联合硫唑嘌呤或甲氨蝶呤治疗，以促进泼尼松龙的减量。
