Institute of Nephrology, Structural Pathology, Chuo-ku Niigata, Niigata, Japan.
Adv Chronic Kidney Dis. 2010 Nov;17(6):487-92. doi: 10.1053/j.ackd.2010.09.005.
Databases which are useful for proteomic analysis of human kidney tissue and urine have been discussed in this article. Integration of the gene-centric and protein-centric general databases with those of human kidney tissue and urine proteomes may open a new window for research in nephrology. Proteins present in the kidney and urine provide basic tools for investigation of kidney function and disease. By comparing such databases between the healthy and diseased populations, we may be able to identify the following: proteins involved in the development of renal disease, proteins involved in progression of CKD, or new biomarker candidate proteins for either the development of renal disease or the progression of CKD.
本文讨论了有助于人类肾脏组织和尿液蛋白质组学分析的数据库。将以基因和蛋白质为中心的通用数据库与人类肾脏组织和尿液蛋白质组数据库相整合，可能为肾脏病学研究开辟新的窗口。肾脏和尿液中的蛋白质为研究肾脏功能和疾病提供了基本工具。通过比较健康人群和患病人群之间的这些数据库，我们也许能够鉴定出：参与肾脏疾病发展的蛋白质、参与 CKD 进展的蛋白质，或者用于肾脏疾病发展或 CKD 进展的新生物标志物候选蛋白质。
