Zhang G Q, Qi M, Ke J, Zhang Y G
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):308-10.
Trihexyphenidyl (Tri) inhibited the contraction of rabbit basilar artery due to high K+ (45.6 mmol/L). IC50 was 2.9 +/- 0.7 mumol/L. The contractions of basilar and mesenteric arteries due to calcium and those of basilar artery and saphenous vein due to serotonin were noncompetitively. Tri inhibited myogenic activities of the portal vein strips of rats and increased the normal cerebral blood flow of rats to 19 +/- 7 ml/(min.100 g).
苯海索（Tri）抑制了高钾（45.6 mmol/L）引起的兔基底动脉收缩。半数抑制浓度（IC50）为2.9±0.7 μmol/L。钙引起的基底动脉和肠系膜动脉收缩以及5-羟色胺引起的基底动脉和隐静脉收缩均为非竞争性的。苯海索抑制大鼠门静脉条的肌源性活动，并使大鼠正常脑血流量增加至19±7 ml/（min·100 g）。
