朝向新的方向：乳腺癌脑转移中的药物渗透性。
Heading in a new direction: drug permeability in breast cancer brain metastasis.
机构信息
Indiana University Simon Cancer Center, Indianapolis, Indiana, USA.
出版信息
Clin Cancer Res. 2010 Dec 1;16(23):5605-7. doi: 10.1158/1078-0432.CCR-10-2502. Epub 2010 Nov 2.
Abstract
Systemic therapies for breast cancer brain metastasis are largely unsuccessful. Mouse models of brain metastasis show significant heterogeneity in uptake of paclitaxel and doxorubicin, with average levels more than those seen in normal brain tissue, but significantly less than in metastases to other organs.
摘要
乳腺癌脑转移的全身治疗大多无效。脑转移的小鼠模型显示出对紫杉醇和阿霉素摄取的显著异质性，平均水平高于正常脑组织，但明显低于转移到其他器官的水平。
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