Diéras Véronique, Pierga Jean-Yves
Institut Curie, département d'oncologie médicale, unité d'investigation clinique, 25, rue d'Ulm, 75248 Paris Cedex 05, France.
Bull Cancer. 2011 Apr;98(4):385-9. doi: 10.1684/bdc.2011.1336.
Brain metastases are prevalent in solid tumours and lymphomas. They are associated with poor survival. The brain is regarded as a sanctuary site for metastatic tumour cells where they exist partially protected from drugs by the blood brain barrier. Amongst the different molecular sub-types of breast cancer, HER2 positive tumours and triple negative tumours exhibit the highest incidence of brain metastasis. Specific strategies are needed to fight brain metastatic disease. Preclinical models for brain metastasis have been developed, yielding mechanistic molecular knowledge and new therapeutic approaches.
脑转移在实体瘤和淋巴瘤中很常见。它们与生存率低有关。大脑被视为转移性肿瘤细胞的庇护所，在那里它们受到血脑屏障的部分保护，免受药物影响。在乳腺癌的不同分子亚型中，HER2阳性肿瘤和三阴性肿瘤的脑转移发生率最高。需要采取特定策略来对抗脑转移性疾病。已经开发出脑转移的临床前模型，产生了分子机制方面的知识和新的治疗方法。
