Dashti-Khavidaki Simin, Khalili Hossein, Gholamalipour Farid, Soudbakhsh Abdolreza, Talasaz Azita-Hajhossein, Hajabdolbaghi Mahboobeh, Rasoolinejad Mehrnaz, Mokhtari Azad Talat, Fathi Mehdi, Talebian Mohammad Taghi, Nasiripour Somayeh
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Infect Dev Ctries. 2010 Oct 28;4(10):629-35. doi: 10.3855/jidc.1195.
Pandemic H1N1 influenza A (pdmH1N1) was a major health threat worldwide.
A prospective cross-sectional study was conducted at Imam Khomeini Hospital in Iran. Cases of suspicious pdmH1N1 patients referred to the emergency ward of the hospital were enrolled in the study, regardless of whether the final location of treatment was the community, the hospital ward, or the intensive care unit. Oseltamivir was administered within three hours of the patient's admission. The median length of stay for hospitalized patients was 3 days.
Gastrointestinal symptoms (nausea [164/434; 37.8%] and vomiting [98/434; 22.6%]) were the most common adverse reactions to oseltamivir in the study population, followed by dizziness (74/434; 17.1%). Out of 434 patients, 209 (48.2%) were treated in the community, 201 (46.3%) were admitted to the general ward in the hospital, and 24 (5.5%) were admitted to an ICU.
This study provided insight on the effectiveness of oseltamivir in treating pandemic influenza A, as well as possible adverse reactions to the drug. The study further drew attention to a variety of pdmH1N1 complications, in particular secondary bacterial pneumonia. We also determined that 2009 influenza A (H1N1) infection-related critical illness and mortality affected fewer elderly than younger patients. Additionally, it was shown that our approach to patients with suspected Influenza A/H1N1 virus in our hospital was compatible with World Health Organization pandemic flu guidelines in our country.
甲型H1N1流感大流行是全球主要的健康威胁。
在伊朗伊玛目霍梅尼医院进行了一项前瞻性横断面研究。转诊至该医院急诊科的疑似甲型H1N1流感患者被纳入研究，无论最终治疗地点是社区、医院病房还是重症监护病房。在患者入院后三小时内给予奥司他韦。住院患者的中位住院时间为3天。
在研究人群中，胃肠道症状（恶心[164/434；37.8%]和呕吐[98/434；22.6%]）是奥司他韦最常见的不良反应，其次是头晕（74/434；17.1%）。434名患者中，209名（48.2%）在社区接受治疗，201名（46.3%）被收治入院普通病房，24名（5.5%）被收治入重症监护病房。
本研究提供了关于奥司他韦治疗甲型流感大流行有效性以及该药物可能的不良反应的见解。该研究进一步关注了多种甲型H1N1流感并发症，特别是继发性细菌性肺炎。我们还确定，2009年甲型H1N1流感感染相关的危重症和死亡率在老年患者中比年轻患者中更少。此外，结果表明，我院对疑似甲型H1N1流感病毒患者的治疗方法符合我国世界卫生组织大流行性流感指南。
