Agabi Yusuf A, Banwat Edmund B, Mawak John D, Lar Patricia M, Dashe Nanma, Dashen Michael M, Adoga Moses P, Agabi Felicia Y, Zakari Hashimu
Department of Microbiology, Faculty of Natural Sciences, University of Jos, Jos, Nigeria.
J Infect Dev Ctries. 2010 Oct 4;4(9):572-5. doi: 10.3855/jidc.567.
Infection with Herpes Simplex Virus Type-2 (HSV-2) is the primary cause of genital herpes and the most common cause of genital ulcer disease (GUD) worldwide. There is little information on the prevalence of HSV-2 in Nigeria.
Specimens were collected from 162 volunteers attending Jos University Teaching Hospital and tested for HSV-2 antibodies using HSV-2 Type specific IgG EIA test kit (Globalemed LLC Alexandria VA, USA). Data were analyzed using SPSS version 13.0. P values ≤ 0.05 were considered significant number.
Out of the 162 individuals tested, 141 (87.0%) were HSV-2 positive. Infected individuals were more likely to be male than female (92.8% versus 86.4%; P > 0.05). There were high rates of infection in all age groups, and the prevalence increased with age. However, multivariate logistic regression analysis showed that HSV-2 prevalence was not significantly associated with increasing age, sex, marital status, occupation, educational status, and number of sex partners (P > 0.05).
The results highlight the potential public health impact of HSV-2 in Nigeria where anti-HSV-2 testing is not generally performed in all populations, especially considering the risk of neonatal transmission and the attendant complications at birth.
2型单纯疱疹病毒（HSV-2）感染是生殖器疱疹的主要病因，也是全球生殖器溃疡疾病（GUD）最常见的病因。关于尼日利亚HSV-2的流行情况，相关信息较少。
从乔斯大学教学医院的162名志愿者中采集样本，使用HSV-2型特异性IgG酶免疫分析检测试剂盒（美国弗吉尼亚州亚历山德里亚市Globalemed有限责任公司）检测HSV-2抗体。使用SPSS 13.0版软件对数据进行分析。P值≤0.05被视为具有显著意义。
在接受检测的162人中，141人（87.0%）HSV-2呈阳性。感染个体中男性比女性更常见（92.8%对86.4%；P>0.05）。所有年龄组的感染率都很高，且患病率随年龄增长而增加。然而，多因素逻辑回归分析表明，HSV-2患病率与年龄增长、性别、婚姻状况、职业、教育程度和性伴侣数量无显著关联（P>0.05）。
这些结果凸显了HSV-2在尼日利亚对公共卫生的潜在影响，尤其是考虑到新生儿传播风险以及出生时随之而来的并发症，而该国并非对所有人群普遍进行抗HSV-2检测。
