Okonko Iheanyi Omezuruike, Cookey Tochi Ifeoma
Medical Microbiology Unit, Department of Microbiology, University of Port Harcourt, Nigeria.
Afr Health Sci. 2015 Sep;15(3):737-47. doi: 10.4314/ahs.v15i3.6.
This study is the first documented prevalence of IgG antibody against HSV-1&-2 in Port Harcourt, Nigeria and thus provides baseline data for future in-depth studies on HSV infection in South-South, Nigeria.
This study determined the seropositivity and determinants of serum IgG antibody against HSV-1 & HIV-2 among pregnant women attending BMSH, Port Harcourt, Rivers State, Nigeria.
Serum samples from 180 pregnant women attending antenatal clinic at Braithwaite Memorial Specialist Hospital (BMSH) in Port Harcourt, Nigeria. Serum samples were analysed with commercial HSV type-1&-2 specific IgG Enzyme Linked Immunosorbent Assay (ELISA) kits. Chi-square analysis was used to determine the association of infection with socio-demographic variables.
Of the 180 pregnant women, 179 (99.4%) were seropositive and 1(0.6%) was seronegative for HSV 1&2 IgG antibody. No statistical association existed between the prevalence of HSV-1&-2 IgG antibodies and the socio-demographic variables studied (p>0.05) except for marital status which was significantly associated (p<0.05).
Our data shows that HSV-1 & 2 seropositivity among pregnant women in Port Harcourt is high; thus serological screening for HSV-1&-2 might be advisable for antenatal attendees.
本研究首次记录了尼日利亚哈科特港人群中抗单纯疱疹病毒1型和2型IgG抗体的流行情况，从而为未来尼日利亚南南地区单纯疱疹病毒感染的深入研究提供了基线数据。
本研究确定了在尼日利亚河流州哈科特港BMSH医院就诊的孕妇中抗单纯疱疹病毒1型和2型血清IgG抗体的血清阳性率及其决定因素。
采集了来自尼日利亚哈科特港Braithwaite纪念专科医院（BMSH）产前诊所的180名孕妇的血清样本。使用商业化的单纯疱疹病毒1型和2型特异性IgG酶联免疫吸附测定（ELISA）试剂盒对血清样本进行分析。采用卡方分析确定感染与社会人口统计学变量之间的关联。
在这180名孕妇中，179名（99.4%）抗单纯疱疹病毒1型和2型IgG抗体血清呈阳性，1名（0.6%）血清呈阴性。除婚姻状况存在显著关联（p<0.05）外，单纯疱疹病毒1型和2型IgG抗体的流行率与所研究的社会人口统计学变量之间不存在统计学关联（p>0.05）。
我们的数据表明，哈科特港孕妇中单纯疱疹病毒1型和2型血清阳性率很高；因此，对产前检查者进行单纯疱疹病毒1型和2型血清学筛查可能是可取的。
