Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Neurol India. 2010 Sep-Oct;58(5):781-3. doi: 10.4103/0028-3886.72209.
Central nervous system primary malignant melanoma accounts for approximately 1% of all melanomas. Primary spinal melanomas are even more unusual. We report a patient with primary spinal melanoma of the cervical leptomeninges. The histology of the tumor showed tumor cells arranged in sheets, ill-defined fascicles and nests and displayed a moderate grade of cellular and nuclear pleomorphism and mitoses with abundant pigment in the cytoplasm. The tumor cells were immunoreactive for HMB-45, and for S-100.
中枢神经系统原发性恶性黑色素瘤约占所有黑色素瘤的 1%。原发性脊髓黑色素瘤更为罕见。我们报告了一例颈髓软脑膜原发性脊髓黑色素瘤患者。肿瘤的组织学表现为肿瘤细胞呈片状、界限不清的束状和巢状排列，具有中度的细胞和核多形性及有丝分裂，并伴有丰富的胞质色素。肿瘤细胞免疫组化 HMB-45 和 S-100 阳性。
