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原发性髓外脊髓黑色素瘤酷似脊髓脑膜瘤:一例报告及文献复习

Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review.

作者信息

Li Yu-Ping, Zhang Heng-Zhu, She Lei, Wang Xiao-Dong, Dong Lun, Xu Enxi, Wang Xing-Dong

机构信息

Department of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

Department of Neurosurgery, Zhenjiang First People's Hospital, Zhenjiang, Jiangsu 212002, P.R. China.

出版信息

Oncol Lett. 2014 Jul;8(1):339-344. doi: 10.3892/ol.2014.2099. Epub 2014 Apr 28.

Abstract

Primary spinal melanoma is a rare lesion, which occurs throughout the cranial and spinal regions, however, is primarily observed in the middle or lower thoracic spine. The clinical features of primary spinal melanoma are complex and unspecific, resulting in a high misdiagnosis rate. In the present case report, a rare case of spinal melanoma exhibiting the dural tail sign and mimicking spinal meningioma is reported. The initial diagnosis, using magnetic resonance imaging (MRI), was unclear. Thus, melanin-containing tumors and spinal meningioma should have been considered in the differential diagnosis. The tumor was completely resected using a standard posterior midline approach, which was followed by chemotherapy. Subsequent to the surgery, the patient was discharged with improved motor capacity and a follow-up MRI scan showed no recurrence after six months. The present study demonstrates that it is critical for neurosurgeons to focus on increasing the accuracy of initial diagnoses in order to make informed decisions regarding the requirement for surgical resection. The present case report presents the clinical, radiological and pathological features of primary extramedullary spinal melanoma mimicking spinal meningioma to emphasize the importance of early identification and diagnosis.

摘要

原发性脊柱黑色素瘤是一种罕见的病变,可发生于整个颅脊柱区域,但主要见于胸段脊柱中下段。原发性脊柱黑色素瘤的临床特征复杂且不具特异性,导致误诊率较高。在本病例报告中,报道了1例罕见的表现为硬膜尾征且酷似脊膜瘤的脊柱黑色素瘤。最初使用磁共振成像(MRI)进行诊断时并不明确。因此,在鉴别诊断中应考虑含黑色素肿瘤和脊膜瘤。采用标准后正中入路将肿瘤完整切除,随后进行化疗。术后患者出院时运动能力有所改善,6个月后的随访MRI扫描显示无复发。本研究表明,神经外科医生关键在于提高初始诊断的准确性,以便就是否需要手术切除做出明智决策。本病例报告展示了酷似脊膜瘤的原发性髓外脊柱黑色素瘤的临床、影像学和病理学特征,以强调早期识别和诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a61/4063659/5ba3062bf1ef/OL-08-01-0339-g00.jpg

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