Division Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany.
Breast Cancer Res Treat. 2011 Jun;127(2):549-54. doi: 10.1007/s10549-010-1244-x. Epub 2010 Nov 3.
MicroRNAs (miRNAs) are 20-22 nt non-coding RNAs which promote the degradation of target mRNAs or repression of the translation of mRNAs by sequence specific targeting. Many miRNAs are considered as oncogenes or tumor suppressors. MiR-126 and miR-335 play roles in the suppression of breast cancer metastasis by inhibiting tumor growth, proliferation, and cell invasion. The effects of SNPs within the two miRNAs are still unknown. In our study, we analyzed two SNPs, rs4636297 within miR-126 and rs41272366 within miR-335, in three study populations for a putative association with breast cancer risk. We compared the genotype and allele frequencies of rs4636297 and rs41272366 in 2854 cases versus 3188 controls of the three study populations independently and combined. None of the performed analyses showed statistically significant results. In conclusion, our data suggest that the two genetic variants within miR-126 and miR-335 are not associated with breast cancer risk.
微小 RNA（miRNA）是 20-22 个核苷酸的非编码 RNA，通过序列特异性靶向促进靶 mRNA 的降解或抑制 mRNA 的翻译。许多 miRNA 被认为是癌基因或肿瘤抑制因子。miR-126 和 miR-335 通过抑制肿瘤生长、增殖和细胞侵袭来发挥抑制乳腺癌转移的作用。这两个 miRNA 内 SNP 的作用尚不清楚。在我们的研究中，我们分析了 miR-126 内的 rs4636297 和 miR-335 内的 rs41272366 这两个 SNP，在三个研究人群中分析它们与乳腺癌风险的潜在关联。我们分别对三个研究人群中的 2854 例病例和 3188 例对照进行了 rs4636297 和 rs41272366 的基因型和等位基因频率比较，并进行了合并分析。进行的分析均未显示出统计学上显著的结果。综上所述，我们的数据表明，miR-126 和 miR-335 内的这两个遗传变异与乳腺癌风险无关。
