甘草酸二铵壳聚糖纳米粒的制备及药效学评价
[Preparation and pharmacodynamic evaluation of diammonium glycyrrhizinate-loaded chitosan nanoparticles].
作者信息
Zhu Yunfeng, Cao Qingri, Yang Shilin, Cui Jinghao
机构信息
School of Phannrmacy, Medical College of Soochow University, Suzhou 21512, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2138-41.
OBJECTIVE
To prepare the diammonium glycyrrhizinate-loaded chitosan nanoparticles (DG-CS NPs), and evaluate its pharmaceutical properties and pharmacodynamic effects on ulcerative colitis (UC).
METHOD
DG-CS NPs were prepared by spray drying method and optimized by orthogonal design. The morphology, size and in vitro release of DG-CS NPs were investigated. The therapeutic effects of DG-CS NPs on UC mice induced by dextran sulfate were evaluated preliminarily through disease active index method.
RESULT
The size of DG-CS NPs with loading capacity about (51.25 +/- 1.75)% was in the range of 300-600 nm. The release of DG-CS NPs was associated with environmental pH value and displayed significant therapeutic and preventive effects on UC.
CONCLUSION
DG-CS NPs prepared by spray drying method showed efficacy on UC mice.
目的
制备载甘草酸二铵的壳聚糖纳米粒（DG-CS NPs），并评价其对溃疡性结肠炎（UC）的药学性质和药效学作用。
方法
采用喷雾干燥法制备DG-CS NPs，并通过正交设计进行优化。考察DG-CS NPs的形态、粒径及体外释放情况。通过疾病活动指数法初步评价DG-CS NPs对葡聚糖硫酸钠诱导的UC小鼠的治疗作用。
结果
载药量约为（51.25±1.75）%的DG-CS NPs粒径在300-600 nm范围内。DG-CS NPs的释放与环境pH值有关，对UC具有显著的治疗和预防作用。
结论
喷雾干燥法制备的DG-CS NPs对UC小鼠具有疗效。
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