Sodhi Candy, Pramod John, Singh Joydeep, Kaur Vaneet
Department of Physiology, Christian Medical College, Ludhiana 141 008.
Indian J Physiol Pharmacol. 2010 Jan-Mar;54(1):69-72.
The study was conducted on 100 pregnant women in third trimester of uncomplicated pregnancy (Test group) and 100 age-matched non-pregnant women (Control group) in the age group of 25 to 35 years. Pulmonary function test parameters FVC, FEV1, PEFR and FEF25-75% recorded using Medspiror. The FEV1/FVC ratio was calculated. All parameters except FEV1/ FVC ratio were found to decline in the Test group as compared to the Control group. The decrease in FEV1 with pregnancy was not of such amplitude as decrease in FVC, and hence FEV1/FVC ratio was seen to increase. This study validates the physiological changes in pulmonary function brought by pregnancy and highlights the need to compile expected and accepted alterations in predicted values of PFT in comparison with the non gravid states for safer outcome of the pregnancy.
该研究针对100名处于妊娠晚期且无并发症的孕妇（试验组）以及100名年龄在25至35岁之间、年龄匹配的非孕妇（对照组）进行。使用Medspiror记录肺功能测试参数FVC、FEV1、PEFR和FEF25 - 75%。计算FEV1/FVC比值。与对照组相比，试验组中除FEV1/FVC比值外的所有参数均下降。妊娠时FEV1的下降幅度不如FVC的下降幅度大，因此FEV1/FVC比值升高。本研究验证了妊娠引起的肺功能生理变化，并强调需要汇编与非妊娠状态相比肺功能测试预测值的预期和可接受变化，以实现更安全的妊娠结局。
