Gulati Kavita, Ray Arunabha, Vijayan V K
Department of Pharmacology and Clinical Research Centre, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 10 007, India.
Indian J Exp Biol. 2010 Mar;48(3):318-22.
The present study evaluated the possible protective role of Livina (a polyherbal preparation) against anti-tubercular therapy (ATT)-induced liver dysfunction in patients of pulmonary tuberculosis. Patients were given intensive phase treatment with 4-drugs (rifampicin, INH, pyrazinamide and ethambutol) used for anti-tubercular therapy for 2 months, followed by a 4-month continuous phase treatment with 2 drugs (rifampicin and INH) under clinical advice and supervision. Both qualitative and quantitative measures of liver function were assessed, at different time intervals, before and after ATT. Analysis of data showed that the incidence of qualitative manifestations of liver dysfunction were greater in the placebo treated group as compared to the test drug group. None of the patients of either group showed clinical jaundice. Most signific changes ant were observed in the SGOT and SGPT levels in the placebo group, wherein the levels of both enzymes were higher at 4 and 8 weeks post-ATT, as compared to the respective baseline (0 week) values. When Livina (2 capsules twice daily) was given with ATT drugs, incidence of qualitative manifestation of liver dysfunction was insignificant and SGOT and SGPT levels were also significantly lower than the placebo+AITT drugs treated group. These results indicate that the test drug (Livina) was efficacious, against ATT-induced hepatic dysfunction in patients of pulmonary tuberculosis.
本研究评估了Livina（一种多草药制剂）对肺结核患者抗结核治疗（ATT）所致肝功能障碍可能的保护作用。患者接受为期2个月的强化期治疗，使用4种抗结核药物（利福平、异烟肼、吡嗪酰胺和乙胺丁醇），随后在临床建议和监督下接受为期4个月的持续期治疗，使用2种药物（利福平和异烟肼）。在ATT前后的不同时间间隔，对肝功能进行了定性和定量评估。数据分析表明，与试验药物组相比，安慰剂治疗组肝功能障碍定性表现的发生率更高。两组患者均未出现临床黄疸。安慰剂组中观察到的最显著变化是谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）水平，与各自的基线（0周）值相比，ATT后4周和8周时这两种酶的水平均较高。当Livina（每日2次，每次2粒胶囊）与ATT药物一起服用时，肝功能障碍定性表现的发生率不显著，SGOT和SGPT水平也显著低于安慰剂+ATT药物治疗组。这些结果表明，试验药物（Livina）对肺结核患者ATT所致肝功能障碍有效。
