Gude D, Bansal D P
Department of Internal Medicine, Medwin Hospital, Nampally, Hyderabad-500 001, India.
Indian J Pharm Sci. 2011 Nov;73(6):663-5. doi: 10.4103/0250-474X.100241.
Antitubercular therapy (ATT) induced hepatotoxicity, although well known to clinicians, is often over looked and underrated. Given the low threshold of starting ATT, especially empirically, the adverse manifestations can take a considerable toll. A variety of associated risk factors compound the morbidity. We throw light on one such a case where ATT was detrimental to the patient and review the literature and possible preventive strategies.
抗结核治疗(ATT)引起的肝毒性,尽管临床医生对此熟知,但常常被忽视和低估。鉴于开始ATT的阈值较低,尤其是经验性用药时,其不良反应可能会造成相当大的损害。多种相关风险因素使发病率进一步增加。我们阐述了一个ATT对患者有害的病例,并回顾了相关文献及可能的预防策略。