The WCU Center for Synthetic Polymer Bioconjugate Hybrid Materials, Department of Polymer Science and Engineering, Pusan National University, Pusan 609-735, Korea.
Langmuir. 2010 Dec 7;26(23):18442-53. doi: 10.1021/la103483c. Epub 2010 Nov 3.
Biocompatible hyperbranched polyglycidol (HBP) has been demonstrated to be an effective reducing and stabilizing agent for the synthesis of highly water-soluble monometallic (Au, Ag, Pt, Pd, and Ru) and bimetallic (Au/Pt, Au/Pd, and Au/Ru) nanoparticles (NPs), which provides a general and green protocol to fabricate metal NPs. The HBP-assisted reduction of metal ions follows an analogous polyol process. The reduction reaction rate increases sharply by increasing the temperature and the molecular weight of HBP. The size of NPs is controllable simply by changing the concentration of the metal precursor. High molecular weight HBP is favorable for the formation of NPs with uniform size and improved stability. By utilizing hydroxyl groups in the HBP-passivation layer of Au NPs, TiO(2)/Au, GeO(2)/Au, and SiO(2)/Au nanohybrids are also fabricated via sol-gel processes, which sets a typical example for the creation of versatile metal NPs/inorganic oxide hybrids based on the as-prepared multifunctional NPs.
生物相容性超支化聚缩水甘油（HBP）已被证明是一种有效的还原和稳定剂，可用于合成高水溶性的单金属（Au、Ag、Pt、Pd 和 Ru）和双金属（Au/Pt、Au/Pd 和 Au/Ru）纳米粒子（NPs），为制备金属 NPs 提供了一种通用且绿色的方案。HBP 辅助的金属离子还原遵循类似的多元醇过程。通过升高温度和 HBP 的分子量，还原反应速率急剧增加。通过改变金属前体的浓度，可以简单地控制 NPs 的尺寸。高分子量的 HBP 有利于形成具有均匀尺寸和提高稳定性的 NPs。通过利用 Au NPs 中 HBP 钝化层上的羟基，还通过溶胶-凝胶工艺制备了 TiO(2)/Au、GeO(2)/Au 和 SiO(2)/Au 纳米杂化材料，为基于所制备的多功能 NPs 构建多功能金属 NPs/无机氧化物杂化材料树立了典型范例。
