RecQ DNA 解旋酶在 DNA 修复中的作用。
The RecQ DNA helicases in DNA repair.
机构信息
Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032, USA.
出版信息
Annu Rev Genet. 2010;44:393-417. doi: 10.1146/annurev-genet-102209-163602.
Abstract
The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.
摘要
RecQ 解旋酶在从细菌到人类的生物中都得到了保守，并且在基因组稳定性中发挥着关键作用。在人类中，RecQ 基因功能的丧失与癌症易感性和/或早衰有关。最近的实验表明，RecQ 解旋酶在 DNA 修复的不同步骤中发挥作用；DNA 末端切除、置换环（D 环）处理、分支迁移和双链 Holliday 结（dHJ）的解决。RecQ 在这些不同的处理步骤中的功能对其在复制和减数分裂过程中双链断裂（DSBs）修复中的作用以及在特定基因组位置（如端粒）的作用具有重要意义。
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