硝苯地平对硝酸甘油静脉扩张反应的影响。

Effects of nifedipine on the venodilatory response to nitroglycerin.

作者信息

Gascho J A, Apollo W P

机构信息

Division of Cardiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

出版信息

Am J Cardiol. 1990 Jan 1;65(1):99-102. doi: 10.1016/0002-9149(90)90033-w.

DOI:10.1016/0002-9149(90)90033-w

PMID:2104736

Abstract

The venodilatory effect of nifedipine 10 mg orally and the venodilatory effect of nitroglycerin 0.8 mg spray after pretreatment with nifedipine were assessed in 15 healthy men aged 22 to 41 years. Compared to placebo, nifedipine caused arteriolar dilation but did not venodilate (control VV[30] 3.67 +/- 0.24 [mean +/- standard error of the mean], after nifedipine VV[30] 3.41 +/- 0.22 cc/100 cc arm). The venodilatory effect of nitroglycerin was not altered by pretreatment with nifedipine. VV[30] increased by 0.72 +/- 0.14 cc/100 cc arm after nitroglycerin in subjects pretreated with placebo compared to 0.70 +/- 0.09 cc/100 cc arm in subjects pretreated with nifedipine. These results suggest that, at a dose of 10 mg, nifedipine does not venodilate and the venodilatory effect of nitroglycerin is not altered by pretreatment with nifedipine.

摘要

在15名年龄在22至41岁的健康男性中，评估了口服10毫克硝苯地平的静脉扩张作用以及硝苯地平预处理后0.8毫克硝酸甘油喷雾剂的静脉扩张作用。与安慰剂相比，硝苯地平引起小动脉扩张，但未引起静脉扩张（安慰剂组VV[30]为3.67±0.24[平均值±平均标准误差]，硝苯地平组VV[30]为3.41±0.22毫升/100毫升手臂）。硝苯地平预处理未改变硝酸甘油的静脉扩张作用。安慰剂预处理的受试者在使用硝酸甘油后，VV[30]增加了0.72±0.14毫升/100毫升手臂，而硝苯地平预处理的受试者为0.70±0.09毫升/100毫升手臂。这些结果表明，10毫克剂量的硝苯地平不会引起静脉扩张，且硝苯地平预处理不会改变硝酸甘油的静脉扩张作用。