Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
Ann Gen Psychiatry. 2010 Nov 3;9:37. doi: 10.1186/1744-859X-9-37.
Benzodiazepines carry the risk of inducing cognitive impairments, which may go unnoticed while profoundly disturbing social activity. Furthermore, these impairments are partly associated with the elimination half-life (EH) of the substance from the body. The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects.
Healthy people were administered etizolam and ethyl loflazepate acutely and subchronically (14 days). The auditory P300 event-related potential and the neuropsychological batteries described below were employed to assess the effects of drugs on cognition. The P300 event-related potential was recorded before and after drug treatments. The digit symbol test, trail making test, digit span test and verbal paired associates test were administered to examine mental slowing and memory functioning.
Acute administration of drugs caused prolongation in P300 latency and reduction in P300 amplitude. Etizolam caused a statistically significant prolongation in P300 latency compared to ethyl loflazepate. Furthermore, subchronic administration of etizolam, but not ethyl loflazepate, still caused a weak prolongation in P300 latency. In contrast, neuropsychological tests showed no difference.
The results indicate that acute administration of ethyl loflazepate induces less effect on P300 latency than etizolam.
苯二氮䓬类药物具有引起认知障碍的风险，而这些认知障碍可能在严重干扰社交活动的同时被忽视。此外，这些损害部分与药物从体内消除半衰期（EH）有关。本研究的目的是检查分别具有 6 小时和 122 小时 EH 的艾司唑仑和依替唑仑对健康受试者信息处理的影响。
健康人急性和亚慢性（14 天）给予艾司唑仑和依替唑仑。听觉 P300 事件相关电位和下文描述的神经心理学测试用于评估药物对认知的影响。在药物治疗前后记录 P300 事件相关电位。进行数字符号测试、连线测试、数字跨度测试和言语配对联想测试，以检查精神运动速度和记忆功能。
药物的急性给药导致 P300 潜伏期延长和 P300 幅度降低。与依替唑仑相比，艾司唑仑导致 P300 潜伏期的统计学显著延长。此外，艾司唑仑的亚慢性给药仍导致 P300 潜伏期的轻微延长，但依替唑仑没有。相比之下，神经心理学测试没有差异。
结果表明，依替唑仑的急性给药对 P300 潜伏期的影响小于艾司唑仑。
