Higashima Masato, Nagasawa Tatsuya, Kawasaki Yasuhiro, Oka Takashi, Sakai Naoto, Tsukada Takahiro, Koshino Yoshifumi
Department of Psychiatry and Neurobiology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan.
Schizophr Res. 2003 Feb 1;59(2-3):147-57. doi: 10.1016/s0920-9964(01)00397-8.
The amplitude of the P300 component of the auditory event-related brain potential (ERP) is consistently reduced in schizophrenia. To determine whether this P300 abnormality can be used as a state marker to reflect the severity of symptoms, we examined both cross-sectionally and longitudinally the relationship between auditory P300 amplitude and symptom severity in patients with schizophrenia. For the cross-sectional study, ERP was elicited by an auditory oddball paradigm, and symptom severity was quantitatively measured by means of the Positive and Negative Syndrome Scale in 93 patients with schizophrenia or schizophreniform disorder (DSM-III-R). For the longitudinal study, ERP and psychopathology measured twice at an average interval of 238 days for 20 patients were retrospectively analyzed. The cross-sectional data showed that P300 amplitude correlated negatively with the positive but not with the negative syndrome scale score. The longitudinal data also showed a significant negative correlation between changes in P300 amplitude and in the positive syndrome scores of the first and second tests. In particular, P300 amplitude recorded at the left, but not right, posterior temporal region significantly correlated with the positive syndrome in both the cross-sectional and longitudinal studies. These findings support the hypotheses that auditory P300 amplitude recorded in the left hemisphere can be used as a state marker to reflect the severity of the positive symptoms and that the positive symptoms may be caused by a possible left-hemisphere deficit in schizophrenia.
精神分裂症患者听觉事件相关脑电位（ERP）的P300成分波幅持续降低。为了确定这种P300异常是否可作为反映症状严重程度的状态标记物，我们对精神分裂症患者听觉P300波幅与症状严重程度之间的关系进行了横断面和纵向研究。在横断面研究中，采用听觉oddball范式诱发ERP，并使用阳性和阴性症状量表对93例精神分裂症或精神分裂症样障碍（DSM-III-R）患者的症状严重程度进行定量测量。在纵向研究中，对20例患者平均间隔238天进行两次测量的ERP和精神病理学数据进行回顾性分析。横断面数据显示，P300波幅与阳性症状量表评分呈负相关，与阴性症状量表评分无相关性。纵向数据还显示，P300波幅变化与第一次和第二次测试的阳性症状评分之间存在显著负相关。特别是，在横断面和纵向研究中，左侧而非右侧颞后区记录的P300波幅与阳性症状显著相关。这些发现支持以下假设：左半球记录的听觉P300波幅可作为反映阳性症状严重程度的状态标记物，且精神分裂症的阳性症状可能由左半球可能存在的缺陷引起。
