Beijing Center for Disease Prevention and Control, Capital Medical University, School of Public Health and Family Medicine, Beijing, PR China.
Prev Med. 2011 Jan;52(1):71-4. doi: 10.1016/j.ypmed.2010.10.006. Epub 2010 Nov 1.
To examine the frequency and distribution of antibodies against pandemic influenza A (H1N1 2009) [H1N1] in populations in Beijing and elucidate influencing factors.
In January 2010, a randomized serologic survey of pandemic influenza A (H1N1 2009) was carried out. Six districts that were randomly selected with a total of 4601 participants involved in the survey have their antibody level tested by hemagglutination inhibition assay.
Among the 4601 participants, the overall seropositive rate for pandemic influenza A (H1N1 2009) antibodies was 31.7%. The seropositivity prevalence in participants who received the pandemic H1N1 vaccination was 60.9%. Only 53.1% of the pandemic influenza A (H1N1 2009) seropositive individuals who had not received the vaccination experienced respiratory tract infection symptoms. Multivariate logistic regression revealed that factors such as age, occupation, dwelling type, whether the participant's family included students in school, and the vaccination history with pandemic influenza A (H1N1 2009) were associated with antibody titers (p<0.05).
Our data indicated that almost 30.0% of the residents had appropriate antibody titers against pandemic influenza A (H1N1 2009) in Beijing, and these titers may provide an immune barrier.
调查北京地区人群中针对甲型 H1N1 流感（H1N1）的抗体频率和分布，并阐明其影响因素。
2010 年 1 月，采用随机血清学调查方法对甲型 H1N1 流感进行了调查。随机选择了 6 个区，共 4601 名参与者接受了血凝抑制试验检测抗体水平。
在 4601 名参与者中，甲型 H1N1 流感抗体的总血清阳性率为 31.7%。接种甲型 H1N1 流感疫苗的参与者的血清阳性率为 60.9%。未接种疫苗的甲型 H1N1 流感抗体阳性者中仅有 53.1%出现呼吸道感染症状。多因素 logistic 回归显示，年龄、职业、居住类型、参与者家庭中是否有在校学生以及甲型 H1N1 流感疫苗接种史等因素与抗体滴度有关（p<0.05）。
本研究数据表明，北京市近 30.0%的居民对甲型 H1N1 流感具有适当的抗体滴度，这些滴度可能提供了免疫屏障。
