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从越南钩藤（防己科）中提取的 N，C-偶联的萘基异喹啉生物碱Ancistrocladinium A 的酚类类似物，具有改善的抗原生动物活性。

Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities.

机构信息

Institute of Organic Chemistry, University of Würzburg, Würzburg, Germany.

出版信息

Phytochemistry. 2011 Jan;72(1):89-93. doi: 10.1016/j.phytochem.2010.10.006. Epub 2010 Nov 1.

DOI:10.1016/j.phytochem.2010.10.006
PMID:21047659
Abstract

The first N,8'-coupled naphthylisoquinoline alkaloids with free phenolic OH groups, 4'-O-demethylancistrocladinium A and 6,4'-O-didemethylancistrocladinium A, have been isolated from the leaves and bark of the Vietnamese liana Ancistrocladus cochinchinensis, along with its known, non-phenolic parent compound, ancistrocladinium A, and four C,C-coupled representatives. The structure elucidation was achieved by chemical, spectroscopic, and chiroptical methods. The mono-phenolic alkaloid showed excellent activities in particular against the pathogen causing Chagas' disease, Trypanosoma cruzi.

摘要

首次从越南藤本植物越南天仙藤的叶和皮中分离得到具有游离酚羟基的第一个 N，8'-偶联的萘基异喹啉生物碱，4'-O-去甲安石榴定 A 和 6,4'-O-二去甲安石榴定 A，以及其已知的非酚性母体化合物安石榴定 A 和四个 C，C-偶联代表物。通过化学、光谱和手性光学方法确定了结构。单酚生物碱对引起恰加斯病的病原体克氏锥虫具有特别优异的活性。

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