Bringmann Gerhard, Dreyer Michael, Michel Manuela, Tayman Francis S K, Brun Reto
Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.
Phytochemistry. 2004 Nov;65(21):2903-7. doi: 10.1016/j.phytochem.2004.05.026.
A new axially chiral naphthylisoquinoline alkaloid, ancistroheynine B (7), has been isolated from the leaves of the Indian liana Ancistrocladus heyneanus Wall., along with two known related alkaloids, ancistrocladidine (3) and ancistrotanzanine C (6), which are 7,3'-coupled, too. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated.
从印度藤本植物Ancistrocladus heyneanus Wall.的叶子中分离出一种新的轴向手性萘基异喹啉生物碱——钩枝藤碱B（7），以及两种已知的相关生物碱——钩枝藤碱（3）和钩枝坦赞宁C（6），它们也是7,3'-偶联的。通过化学、光谱和旋光方法完成了结构解析。对钩枝藤碱B针对疟疾、利什曼病、恰加斯病和非洲昏睡病病原体的生物活性进行了评估。
