IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.
作者信息
Kempuraj Duraisamy, Conti Pio, Vasiadi Magdalini, Alysandratos Konstantinos-Dionysios, Tagen Michael, Kalogeromitros Dimitrios, Kourelis Taxiarchis, Gregoriou Stamatios, Makris Michael, Stavrianeas Nikolaos G, Theoharides Theoharis C
出版信息
Eur J Dermatol. 2010 Nov-Dec;20(6):865-7. doi: 10.1684/ejd.2010.1110. Epub 2010 Nov 4.
Abstract
摘要
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1
IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.白细胞介素-32在银屑病皮损中与类胰蛋白酶一同升高，且在人肥大细胞中被P物质上调。
Eur J Dermatol. 2010 Nov-Dec;20(6):865-7. doi: 10.1684/ejd.2010.1110. Epub 2010 Nov 4.
2
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The presence of tryptase-positive and bikunin-negative mast cells in psoriatic skin lesions.银屑病皮肤病变中存在类胰蛋白酶阳性和 bikunin 阴性的肥大细胞。
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本文引用的文献
1
IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis.IL-32 由人原代角质形成细胞表达，并调节特应性皮炎中角质形成细胞的凋亡。
J Allergy Clin Immunol. 2010 Apr;125(4):858-865.e10. doi: 10.1016/j.jaci.2010.01.016. Epub 2010 Mar 15.
2
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.IL-33 增强了 P 物质诱导的人肥大细胞 VEGF 分泌，并在银屑病皮肤中增加。
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4448-53. doi: 10.1073/pnas.1000803107. Epub 2010 Feb 16.
3
Psoriasis.银屑病
N Engl J Med. 2009 Jul 30;361(5):496-509. doi: 10.1056/NEJMra0804595.
4
Is there a role for mast cells in psoriasis?肥大细胞在银屑病中起作用吗？
Arch Dermatol Res. 2008 Oct;300(9):461-78. doi: 10.1007/s00403-008-0874-x. Epub 2008 Aug 22.
5
Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus.银屑病中P物质及其神经激肽-1受体的研究及其与慢性应激和瘙痒的关系。
Arch Dermatol Res. 2007 May;299(2):85-91. doi: 10.1007/s00403-007-0745-x. Epub 2007 Mar 17.
6
IL-32, a proinflammatory cytokine in rheumatoid arthritis.白细胞介素-32，类风湿关节炎中的一种促炎细胞因子。
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3298-303. doi: 10.1073/pnas.0511233103. Epub 2006 Feb 21.
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