• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.白细胞介素-32在银屑病皮损中与类胰蛋白酶一同升高，且在人肥大细胞中被P物质上调。
Eur J Dermatol. 2010 Nov-Dec;20(6):865-7. doi: 10.1684/ejd.2010.1110. Epub 2010 Nov 4.
2
Mast cell tryptase and chymase in developing and mature psoriatic lesions.发育中和成熟银屑病皮损中的肥大细胞类胰蛋白酶和糜蛋白酶
Arch Dermatol Res. 1993;285(4):184-92. doi: 10.1007/BF00372007.
3
The presence of tryptase-positive and bikunin-negative mast cells in psoriatic skin lesions.银屑病皮肤病变中存在类胰蛋白酶阳性和 bikunin 阴性的肥大细胞。
Arch Dermatol Res. 2007 Feb;298(9):421-6. doi: 10.1007/s00403-006-0704-y. Epub 2006 Dec 5.
4
Mast cell tryptase and chymase are potential regulators of neurogenic inflammation in psoriatic skin.肥大细胞类胰蛋白酶和糜蛋白酶是银屑病皮肤神经源性炎症的潜在调节因子。
Int J Dermatol. 1994 May;33(5):361-6. doi: 10.1111/j.1365-4362.1994.tb01069.x.
5
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions.在银屑病皮损的肥大细胞中，糜酶活性降低与蛋白酶抑制剂水平升高有关。
Acta Derm Venereol. 1999 Mar;79(2):98-104. doi: 10.1080/000155599750011282.
6
Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor.实验性诱导的银屑病病变与肥大细胞中的白细胞介素 (IL)-6 以及表达白细胞介素 (IL)-33 和 IL-6 受体的真皮细胞出现相关。
Clin Exp Immunol. 2012 Sep;169(3):311-9. doi: 10.1111/j.1365-2249.2012.04618.x.
7
Quantitative enzyme-histochemical analysis of tryptase- and chymase-containing mast cells in psoriatic skin.银屑病皮肤中含类胰蛋白酶和糜酶的肥大细胞的定量酶组织化学分析
Arch Dermatol Res. 1990;282(7):428-33. doi: 10.1007/BF00402617.
8
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.IL-33 增强了 P 物质诱导的人肥大细胞 VEGF 分泌，并在银屑病皮肤中增加。
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4448-53. doi: 10.1073/pnas.1000803107. Epub 2010 Feb 16.
9
Mast cells in psoriatic skin are strongly positive for interferon-gamma.银屑病皮肤中的肥大细胞对γ干扰素呈强阳性。
Br J Dermatol. 1999 Apr;140(4):624-33. doi: 10.1046/j.1365-2133.1999.02760.x.
10
Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion.肥大细胞CD30配体在皮肤炎症中上调，并介导不依赖于脱颗粒的趋化因子分泌。
J Clin Invest. 2006 Oct;116(10):2748-56. doi: 10.1172/JCI24274. Epub 2006 Sep 7.

引用本文的文献

1
Salivary Interleukins as Non-Invasive Biomarkers for Psoriasis: Advances and Challenges in Diagnosis and Monitoring.唾液白细胞介素作为银屑病的非侵入性生物标志物：诊断与监测的进展及挑战
Medicina (Kaunas). 2025 Jun 29;61(7):1180. doi: 10.3390/medicina61071180.
2
Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis.解析肝癌肿瘤微环境的异质性和可塑性可为预后提供见解。
Front Pharmacol. 2025 Jan 30;16:1495280. doi: 10.3389/fphar.2025.1495280. eCollection 2025.
3
IL-32 as a potential biomarker and therapeutic target in skin inflammation.白细胞介素 32 作为皮肤炎症的潜在生物标志物和治疗靶点。
Front Immunol. 2023 Sep 1;14:1264236. doi: 10.3389/fimmu.2023.1264236. eCollection 2023.
4
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis.单细胞和空间测序定义了角质形成细胞和成纤维细胞在银屑病中放大炎症反应的过程。
Nat Commun. 2023 Jun 12;14(1):3455. doi: 10.1038/s41467-023-39020-4.
5
Single-cell transcriptomics suggest distinct upstream drivers of IL-17A/F in hidradenitis versus psoriasis.单细胞转录组学表明，大汗腺炎和银屑病中 IL-17A/F 的上游驱动因素不同。
J Allergy Clin Immunol. 2023 Sep;152(3):656-666. doi: 10.1016/j.jaci.2023.05.012. Epub 2023 Jun 2.
6
The Role of Interleukins in the Pathogenesis of Dermatological Immune-Mediated Diseases.白细胞介素在皮肤科免疫介导性疾病发病机制中的作用。
Adv Ther. 2022 Oct;39(10):4474-4508. doi: 10.1007/s12325-022-02241-y. Epub 2022 Aug 23.
7
Mast Cell Cytokines IL-1, IL-33, and IL-36 Mediate Skin Inflammation in Psoriasis: A Novel Therapeutic Approach with the Anti-Inflammatory Cytokines IL-37, IL-38, and IL-1Ra.肥大细胞细胞因子 IL-1、IL-33 和 IL-36 介导银屑病皮肤炎症：抗炎细胞因子 IL-37、IL-38 和 IL-1Ra 的新治疗方法。
Int J Mol Sci. 2021 Jul 28;22(15):8076. doi: 10.3390/ijms22158076.
8
Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis.单细胞转录组分析鉴定出系统性硬化症中的皮肤特异性 T 细胞反应。
Ann Rheum Dis. 2021 Nov;80(11):1453-1460. doi: 10.1136/annrheumdis-2021-220209. Epub 2021 May 24.
9
Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms.科布纳现象导致新的银屑病皮损形成：证据和机制。
Biosci Rep. 2019 Dec 20;39(12). doi: 10.1042/BSR20193266.
10
Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP-1 expression in IL-32γ overexpressed condition.在 IL-32γ 过表达条件下，通过抑制 NF-κB 依赖性 ITGAV 和 TIMP-1 表达抑制皮肤癌发生。
J Exp Clin Cancer Res. 2018 Nov 28;37(1):293. doi: 10.1186/s13046-018-0943-8.

本文引用的文献

1
IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis.IL-32 由人原代角质形成细胞表达，并调节特应性皮炎中角质形成细胞的凋亡。
J Allergy Clin Immunol. 2010 Apr;125(4):858-865.e10. doi: 10.1016/j.jaci.2010.01.016. Epub 2010 Mar 15.
2
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.IL-33 增强了 P 物质诱导的人肥大细胞 VEGF 分泌，并在银屑病皮肤中增加。
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4448-53. doi: 10.1073/pnas.1000803107. Epub 2010 Feb 16.
3
Psoriasis.银屑病
N Engl J Med. 2009 Jul 30;361(5):496-509. doi: 10.1056/NEJMra0804595.
4
Is there a role for mast cells in psoriasis?肥大细胞在银屑病中起作用吗？
Arch Dermatol Res. 2008 Oct;300(9):461-78. doi: 10.1007/s00403-008-0874-x. Epub 2008 Aug 22.
5
Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus.银屑病中P物质及其神经激肽-1受体的研究及其与慢性应激和瘙痒的关系。
Arch Dermatol Res. 2007 May;299(2):85-91. doi: 10.1007/s00403-007-0745-x. Epub 2007 Mar 17.
6
IL-32, a proinflammatory cytokine in rheumatoid arthritis.白细胞介素-32，类风湿关节炎中的一种促炎细胞因子。
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3298-303. doi: 10.1073/pnas.0511233103. Epub 2006 Feb 21.

IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.

作者信息

Kempuraj Duraisamy, Conti Pio, Vasiadi Magdalini, Alysandratos Konstantinos-Dionysios, Tagen Michael, Kalogeromitros Dimitrios, Kourelis Taxiarchis, Gregoriou Stamatios, Makris Michael, Stavrianeas Nikolaos G, Theoharides Theoharis C

出版信息

Eur J Dermatol. 2010 Nov-Dec;20(6):865-7. doi: 10.1684/ejd.2010.1110. Epub 2010 Nov 4.

DOI:10.1684/ejd.2010.1110
PMID:21047723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3273318/
Abstract
摘要