中脑星形胶质细胞衍生神经营养因子（MANF）具有独特的挽救凋亡神经元的机制。
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
机构信息
Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, Finland.
出版信息
J Biol Chem. 2011 Jan 28;286(4):2675-80. doi: 10.1074/jbc.M110.146738. Epub 2010 Nov 3.
Abstract
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well known inhibitor of proapoptotic Bax (Bcl-2-associated X protein). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
摘要
中脑星形胶质细胞衍生神经营养因子（MANF）可保护神经元并修复大鼠 6-羟多巴胺模型中的帕金森病样症状。我们展示了人源 MANF 的三维溶液结构，与其他神经营养因子有很大的不同。值得注意的是，MANF 的 C 端结构域（C-MANF）与 Ku70 的 SAP 结构域同源，后者是促凋亡 Bax（Bcl-2 相关 X 蛋白）的一种众所周知的抑制剂。细胞研究证实，MANF 和 C-MANF 可像 Ku70 一样有效地保护细胞内的神经元。
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