Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Carcinogenesis. 2011 Feb;32(2):190-6. doi: 10.1093/carcin/bgq231. Epub 2010 Nov 3.
A recent study examined associations of tagging single nucleotide polymorphisms (tagSNPs) in 43 fatty acid metabolism-related genes and risk of colorectal cancer (CRC), showing rs8752, rs2612656 and a haplotype [comprising both of the single nucleotide polymorphisms (SNPs)] in the hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) gene to be positively associated with CRC risk. In the present study, we attempted to replicate these single marker and haplotype associations, using 1795 CRC cases and 1805 controls from the German Darmkrebs: Chancen der Verhütung durch Screening study (DACHS). In addition to rs8752 and rs2612656, HPGD tagSNPs rs9312555, rs17360144 and rs7349744 were genotyped for haplotype analyses. Except for a marginally significant inverse association of HPGD rs8752 with CRC risk [odds ratio (OR) = 0.85; 95% confidence interval (CI) = 0.74, 0.98; P = 0.03], none of the analyzed tagSNPs showed any association with CRC. Subset analyses for colon and rectal cancers yielded similar, yet non-significant risk estimates at all five loci. Also, none of the haplotypes was found to be associated with CRC, colon or rectal cancers. However, rs8752 was significantly associated with a decreased risk of CRC among individuals with a body mass index < 30 (OR = 0.82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC.
最近的一项研究检查了 43 个脂肪酸代谢相关基因中的单核苷酸多态性（tagSNPs）与结直肠癌（CRC）风险的关联，结果表明羟前列腺素脱氢酶 15-（NAD）（HPGD）基因中的 rs8752、rs2612656 和单核苷酸多态性（SNP）[由两个单核苷酸多态性（SNP）组成]与 CRC 风险呈正相关。在本研究中，我们试图使用来自德国 Darmkrebs：Chancen der Verhütung durch Screening 研究（DACHS）的 1795 例 CRC 病例和 1805 例对照来复制这些单标记和单体型关联。除了 rs8752 和 rs2612656，还对 HPGD tagSNPs rs9312555、rs17360144 和 rs7349744 进行了基因型分析，以进行单体型分析。除了 HPGD rs8752 与 CRC 风险呈显著负相关[比值比（OR）=0.85；95%置信区间（CI）=0.74，0.98；P=0.03]外，没有分析的 tagSNPs 与 CRC 相关。在所有五个基因座上，对结肠癌和直肠癌的亚组分析得出了类似但无统计学意义的风险估计值。此外，没有发现任何单体型与 CRC、结肠癌或直肠癌相关。然而，rs8752 与 BMI<30 的个体（OR=0.82，95%CI=0.70，0.95，P=0.01）以及吸烟者（OR=0.74，95%CI=0.61，0.90，P=0.003）的 CRC 风险降低显著相关。然而，我们的数据不支持先前报道的 HPGD tagSNPs 与 CRC 风险的关联。
