Department of Psychology and Neuroscience, Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA.
J Neurosci. 2010 Nov 3;30(44):14719-23. doi: 10.1523/JNEUROSCI.3989-10.2010.
Central to the production of adaptive behavior is the ability to learn the temporal order of behavioral elements (e.g., A, B, C). Yet little is known about neural substrates of serial order in self-initiated behavioral sequences. The present study assessed the contributions of specific dorsal striatal regions to the acquisition of serial order in mice, using a two-action sequence task without instructive cues. Excitotoxic lesions of the sensorimotor (dorsolateral) striatum dramatically impaired the acquisition of a simple sequence; in contrast, lesions of the associative (dorsomedial) striatum had no significant effect. Neither lesion caused gross motor impairments or affected the learning of nonsequential actions. These results demonstrate for the first time a critical role of the sensorimotor striatum in the learning of serial order.
自适应行为的产生的关键是学习行为要素（如 A、B、C）的时间顺序的能力。然而，关于自我启动行为序列中序列顺序的神经基质知之甚少。本研究使用无指导线索的两个动作序列任务，评估了特定背侧纹状体区域对小鼠序列顺序习得的贡献。感觉运动（背外侧）纹状体的兴奋毒性损伤显著损害了简单序列的习得；相比之下，联合（背内侧）纹状体的损伤没有显著影响。两种损伤都没有导致明显的运动障碍，也没有影响非序列动作的学习。这些结果首次证明了感觉运动纹状体在序列顺序学习中的关键作用。
