Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
Phys Med Biol. 2010 Nov 21;55(22):6897-910. doi: 10.1088/0031-9155/55/22/019. Epub 2010 Nov 3.
Simultaneous rest perfusion/fatty-acid metabolism studies have the potential to replace sequential rest/stress perfusion studies for the assessment of cardiac function. Simultaneous acquisition has the benefits of increased signal and lack of need for patient stress, but is complicated by cross-talk between the two radionuclide signals. We consider a simultaneous rest (99m)Tc-sestamibi/(123)I-BMIPP imaging protocol in place of the commonly used sequential rest/stress (99m)Tc-sestamibi protocol. The theoretical precision with which the severity of a cardiac defect and the transmural extent of infarct can be measured is computed for simultaneous and sequential SPECT imaging, and their performance is compared for discriminating (1) degrees of defect severity and (2) sub-endocardial from transmural defects. We consider cardiac infarcts for which reduced perfusion and metabolism are observed. From an information perspective, simultaneous imaging is found to yield comparable or improved performance compared with sequential imaging for discriminating both severity of defect and transmural extent of infarct, for three defects of differing location and size.
同时进行的休息期灌注/脂肪酸代谢研究有可能替代顺序进行的休息期/负荷期灌注研究，用于评估心功能。同时采集具有增加信号和无需患者应激的优势，但存在两种放射性核素信号之间串扰的问题。我们考虑用同时进行的（99m）Tc-甲氧基异丁基异腈/（123）I-双碘苯丙氨酸（BMIPP）成像方案替代常用的顺序进行的（99m）Tc-甲氧基异丁基异腈方案。对于同时和顺序单光子发射计算机断层成像（SPECT），我们计算了测量心脏缺陷严重程度和梗塞透壁程度的理论精度，并比较了它们在区分（1）缺陷严重程度和（2）心内膜下与透壁性缺陷方面的性能。我们考虑了灌注和代谢均降低的心脏梗塞情况。从信息角度来看，对于不同位置和大小的三种缺陷，与顺序成像相比，同时成像在区分缺陷严重程度和梗塞透壁程度方面具有相当或更好的性能。
