基于邻苯二甲酰亚胺的荧光肝X受体拮抗剂的设计与合成
Design and synthesis of phthalimide-based fluorescent liver x receptor antagonists.
作者信息
Kishida Kenji, Aoyama Atsushi, Hashimoto Yuichi, Miyachi Hiroyuki
机构信息
Okayama University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1525-8. doi: 10.1248/cpb.58.1525.
PMID:21048348
Abstract
Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.
摘要
基于我们对肝脏X受体（LXR）配体的构效关系研究，我们设计并合成了在邻苯二甲酰亚胺单元上含有未取代或取代氨基的荧光LXR拮抗剂。
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