Matsushita Takashi
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan.
Nihon Rinsho Meneki Gakkai Kaishi. 2010;33(5):234-41. doi: 10.2177/jsci.33.234.
Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5(+) B-1a cells, CD1d(+) marginal zone B cells, and transitional 2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1d(hi)CD5(+)CD19(hi) subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. Remarkably, regulatory B cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of regulatory B cell function is reviewed in the context of previous studies that have identified and characterized regulatory B cells.
产生白细胞介素-10的调节性B细胞如今被视为免疫系统的重要组成部分。来自多个杰出实验室的标志性论文已鉴定出在不同自身免疫性疾病期间具有调节功能的表型多样的B细胞亚群，包括产生白细胞介素-10的B细胞、CD5(+) B-1a细胞、CD1d(+)边缘区B细胞和过渡性2-边缘区前体B细胞。最近，在正常小鼠和自身免疫小鼠的脾脏中均鉴定出了数量稀少且表型独特的调节性B细胞CD1d(hi)CD5(+)CD19(hi)亚群。值得注意的是，在体内疾病的小鼠模型中，调节性B细胞是炎症和自身免疫的有效负调节因子。在此，我们结合先前鉴定和表征调节性B细胞的研究，对调节性B细胞功能的当前理解进行综述。
