Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Ann N Y Acad Sci. 2010 Jan;1183:38-57. doi: 10.1111/j.1749-6632.2009.05137.x.
The ability of B cells to negatively regulate cellular immune responses and inflammation has only recently been described. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B-cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5+ B-1a cells, CD1d+ marginal zone B cells, and transitional-2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1dhiCD5+CD19hi subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. CD1dhiCD5+ B cells with the capacity to produce IL-10 have been named B10 cells as they produce IL-10 exclusively and are the predominant B-cell source of IL-10. Remarkably, B10 cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of B10-cell development and function is reviewed in the context of previous studies that have identified and characterized regulatory B cells, emerging evidence for B10-cell regulation of tumor immunity, and the likelihood that B10 cells exist in humans.
B 细胞负向调控细胞免疫应答和炎症的能力最近才被描述出来。一些杰出实验室的标志性论文已经鉴定出在不同自身免疫性疾病中具有调节功能的表型多样的 B 细胞亚群，包括产生 IL-10 的 B 细胞、CD5+B-1a 细胞、CD1d+边缘区 B 细胞和过渡-2-边缘区前体 B 细胞。最近，在正常和自身免疫性小鼠的脾脏中发现了一种数量较少且表型独特的 CD1dhiCD5+CD19hi 调节性 B 细胞亚群。具有产生 IL-10 能力的 CD1dhiCD5+B 细胞被命名为 B10 细胞，因为它们专门产生 IL-10，并且是 IL-10 的主要 B 细胞来源。值得注意的是，B10 细胞在体内疾病的小鼠模型中是炎症和自身免疫的有效负调节剂。本文综述了 B10 细胞发育和功能的最新认识，同时也考虑了先前研究中鉴定和表征调节性 B 细胞的研究、B10 细胞对肿瘤免疫调节的新证据，以及 B10 细胞可能存在于人类中的可能性。
