Pearce Mark S, Korada Murthy, Day Julie, Turner Steve, Allison David, Kibirige Mohammed, Cheetham Tim D
Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE1 4LP, UK.
J Thyroid Res. 2010 Jan 28;2010:101948. doi: 10.4061/2010/101948.
Previous studies of congenital hypothyroidism have suggested an increasing incidence and seasonal variation in incidence, which may suggest nongenetic factors involved in aetiology. This study describes the incidence of elevated thyroid stimulating hormone (TSH) values in newborns, a surrogate for congenital hypothyroidism, measured as part of the screening programme for congenital hypothyroidism, over an eleven-year period (1994-2005), and assesses whether seasonal variation exists. All infants born in the Northern Region of England are screened by measuring levels of circulating TSH using a blood spot assay. Data on all 213 cases born from 1994 to 2005 inclusive were available. Annual incidence increased significantly from 37 per 100,000 in 1994 to a peak of 92.8 per 100,000 in 2003. There was no evidence of seasonal variation in incidence. The reasons for the increasing incidence are unclear, but do not appear to involve increasing exposure to seasonally varying factors or changes in measurements methods.
以往关于先天性甲状腺功能减退症的研究表明，其发病率呈上升趋势且存在季节性变化，这可能提示病因中存在非遗传因素。本研究描述了在一项为期11年（1994 - 2005年）的先天性甲状腺功能减退症筛查项目中，作为先天性甲状腺功能减退症替代指标的新生儿促甲状腺激素（TSH）值升高的发生率，并评估是否存在季节性变化。英格兰北部地区所有出生的婴儿都通过血斑检测法测量循环TSH水平进行筛查。可获取1994年至2005年（含）期间出生的所有213例病例的数据。年发病率从1994年的每10万例37例显著增加到2003年的每10万例92.8例的峰值。没有证据表明发病率存在季节性变化。发病率上升的原因尚不清楚，但似乎与季节性变化因素暴露增加或测量方法改变无关。
