The events surrounding the removal of encainide and flecainide from the Cardiac Arrhythmia Suppression Trial (CAST) and why CAST is continuing with moricizine.

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作者信息

Bigger J T

机构信息

Department of Medicine, Columbia University, New York, New York 10032.

出版信息

J Am Coll Cardiol. 1990 Jan;15(1):243-5. doi: 10.1016/0735-1097(90)90209-8.

DOI:10.1016/0735-1097(90)90209-8

PMID:2104884

Abstract

摘要

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The events surrounding the removal of encainide and flecainide from the Cardiac Arrhythmia Suppression Trial (CAST) and why CAST is continuing with moricizine.

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Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS.恩卡胺、氟卡胺、丙咪嗪和莫雷西嗪对急性心肌梗死后一年内室性心律失常的影响：CAPS研究

Am J Cardiol. 1988 Mar 1;61(8):501-9. doi: 10.1016/0002-9149(88)90754-0.

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction.初步报告：恩卡胺和氟卡胺在心肌梗死后心律失常抑制随机试验中对死亡率的影响

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An interim perspective on the removal of encainide and flecainide from the cardiac arrhythmia suppression trial.关于从心律失常抑制试验中撤下恩卡胺和氟卡胺的中期观点。

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Consequences of the Cardiac Arrhythmia Suppression Trial: calamity or clarity?心律失常抑制试验的后果：灾难还是启示？

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Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction. A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST).心肌梗死患者的基线特征与恩卡尼、氟卡尼和莫雷西嗪治疗风险的相互作用。心律失常抑制试验（CAST）中死亡率增加的一种可能解释。

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