成人干细胞在骨坏死和骨折不愈合中的 1-3 期临床试验。
Phases 1-3 clinical trials using adult stem cells in osteonecrosis and nonunion fractures.
机构信息
Department of Rheumatology, CHU Sart Tilman, B35, 4000 Liège, Belgium.
出版信息
Stem Cells Int. 2010 Oct 26;2010:410170. doi: 10.4061/2010/410170.
Abstract
NONUNION FRACTURES AND ASEPTIC BONE NECROSIS ARE TWO PATHOLOGICAL CONDITIONS HAVING SOME IMPAIRMENT OF THE CELLULAR PART OF THE REPAIR
a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection-15 to 150 ml-was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.
摘要
非愈合性骨折和无菌性骨坏死是两种具有细胞修复部分损伤的病理状态
MSC 和成骨细胞激活减少。这两种情况都适合使用基于干细胞的细胞治疗。我们对已发表的人体试验进行了综述。到目前为止，仅使用了自体骨髓抽吸物植入。在非愈合性骨折中，有 4 项病例系列研究进行了直接注射（15 至 150ml）。在另一项研究中，骨髓抽吸物在注射前进行了浓缩。结果是好的。在骨坏死中，仅发表了一项 1 级研究。24 个月时，在减少坏死和出现塌陷方面的结果是积极的。在 3 项病例系列研究中，浓缩骨髓抽吸物的治疗被认为是有用的，76%至 96%的结果良好。这些结果很有趣，但需要通过对照研究来证实。
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