组织来源的干细胞和祖细胞。
Tissue-derived stem and progenitor cells.
机构信息
Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7211, USA.
出版信息
Stem Cells Int. 2010;2010:824876. doi: 10.4061/2010/824876. Epub 2009 Oct 28.
Abstract
The characterization and isolation of various stem cell populations, from embryonic through tissue-derived stem cells, have led a rapid growth in the field of stem cell research. These research efforts have often been interrelated as to the markers that identify a select cell population are frequently analyzed to determine their expression in cells of distinct organs/tissues. In this review, we will expand the current state of research involving select tissue-derived stem cell populations including the liver, central nervous system, and cardiac tissues as examples of the success and challenges in this field of research. Lastly, the challenges of clinical therapies will be discussed as it applies to these unique cell populations.
摘要
各种干细胞群体的特征和分离，从胚胎到组织来源的干细胞，已经导致了干细胞研究领域的快速发展。这些研究工作通常是相互关联的，因为识别特定细胞群体的标记物经常被分析，以确定它们在不同器官/组织的细胞中的表达。在这篇综述中，我们将扩展涉及特定组织来源的干细胞群体的研究现状，包括肝脏、中枢神经系统和心脏组织，作为该研究领域成功和挑战的例子。最后，将讨论临床治疗的挑战，因为它适用于这些独特的细胞群体。
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