Omar Souheil, Hadj Taeib Sameh, Kanoun Faouzi, Hammami Mohamed Bassem, Kamoun Samia, Ben Romdhane Neila, Feki Moncef, Slimane Hedia, Kaabachi Naziha
Laboratoire de Biochimie, Service d'Endocrinologie Diabétologie, Hôpital la Rabta, Tunis, Tunisia.
Tunis Med. 2010 Nov;88(11):783-8.
Erythrocyte abnormalities are frequently associated with thyroid dysfunction. However, they are rarely investigated and related to the thyroid.
This study was aimed to determine the nature and frequency of erythrocyte abnormalities in thyroid disease and look for their evolution after thyroid function restoration.
This retrospective study included 412 patients with peripheral thyroid disease; hyperthyroidism (n=235) or hypothyroidism (n=177). Hyperthyroidism was considered for TSH<0.10 ÌUI/ml and hypothyroidism for TSH>5.0 ÌUI/ml. Anemia was defined by hemoglobin level<13 g/dl in men and <12 g/dl in women, microcytosis by mean corpuscular volume (MCV)<80 fl, macrocytosis by MCV>98 fl, and hypochromia by mean corpuscular hemoglobin (MCH)<25 pg. Restoration of euthyroid state was considered in patients with normal TSH levels for at least 3 months.
Anaemia was observed in 40.9% of patients with hyperthyroidism and 57.1% of patients with hypothyroidism. Among these, normocytic or macrocytic anaemia was present in 46.3% of cases. Whereas, microcytosis, with or without anaemia, was noted in 87.7% of patients with hyperthyroidism. FT4 was positively correlated with the number of red blood cells and haemoglobin, and inversely correlated with MCV and MCH. After restoration of euthyroid state, most erythrocyte abnormalities were corrected.
Thyroid diseases are frequently associated with erythrocyte abnormalities, including normocytic anaemia in hypothyroidism and microcytosis in hyperthyroidism. These abnormalities should be investigated and corrected. Their presence could steer towards subclinical thyroid dysfunction, allowing its early management.
红细胞异常常与甲状腺功能障碍相关。然而，它们很少被研究且与甲状腺的关系也鲜为人知。
本研究旨在确定甲状腺疾病中红细胞异常的性质和频率，并观察甲状腺功能恢复后它们的变化情况。
这项回顾性研究纳入了412例外周甲状腺疾病患者；其中甲亢患者（n = 235）或甲减患者（n = 177）。TSH<0.10 μIU/ml被视为甲亢，TSH>5.0 μIU/ml被视为甲减。男性血红蛋白水平<13 g/dl、女性<12 g/dl定义为贫血，平均红细胞体积（MCV）<80 fl定义为小红细胞症，MCV>98 fl定义为大红细胞症，平均红细胞血红蛋白（MCH）<25 pg定义为低色素症。TSH水平正常至少3个月的患者被视为甲状腺功能恢复正常状态。
甲亢患者中40.9%出现贫血，甲减患者中57.1%出现贫血。其中，46.3%的病例为正细胞性或大细胞性贫血。而在甲亢患者中，87.7%的患者出现了伴有或不伴有贫血的小红细胞症。FT4与红细胞数量和血红蛋白呈正相关，与MCV和MCH呈负相关。甲状腺功能恢复正常状态后，大多数红细胞异常得到纠正。
甲状腺疾病常与红细胞异常相关，包括甲减中的正细胞性贫血和甲亢中的小红细胞症。这些异常情况应进行检查并纠正。它们的存在可能提示亚临床甲状腺功能障碍，从而实现早期管理。
