Paraf A, Hanss M, Belfort J
Sem Hop. 1983 Dec 22;59(48):3351-5.
In view of the frequent erythrocyte abnormalities found in liver cirrhosis, erythrocyte deformability was studied in 62 patients. Deformability was determined by the initial filtration flow technique using a Hemorheometer. Results are given as a rigidity index (IR), which is characteristic of the average individual RBC. Deformability was significantly reduced in patients with cirrhosis. No correlation was found with the often increased MCV. A significant positive correlation was found between IR and the cell membrane free cholesterol/phospholipid ration, as the increase in cell rigidity is mainly due to a decrease in the cell membrane sphingomyelin content. The role of reduced RBC deformability in liver cirrhosis anemia still awaits elucidation.
鉴于肝硬化患者中经常发现红细胞异常，对62例患者的红细胞变形性进行了研究。使用血液流变仪通过初始过滤流技术测定变形性。结果以刚性指数（IR）表示，它是个体红细胞平均水平的特征指标。肝硬化患者的变形性显著降低。未发现与常升高的平均红细胞体积（MCV）有相关性。发现IR与细胞膜游离胆固醇/磷脂比值之间存在显著正相关，因为细胞刚性增加主要是由于细胞膜鞘磷脂含量降低。红细胞变形性降低在肝硬化贫血中的作用仍有待阐明。
