Baron N W, Davis L P, Flaherty L E, Muz J, Valdivieso M, Kling G A
Department of Radiology, Harper Hospital, Wayne State University, Detroit, MI 48201.
AJR Am J Roentgenol. 1990 Feb;154(2):327-30. doi: 10.2214/ajr.154.2.2105025.
Interleukin-2 is receiving widespread interest as an immunotherapeutic agent in the treatment of certain cancers. Severe arthralgias recently have been reported as a significant side effect, and the cause of pain is unknown. Because interleukin-2 is an immune modulator, we reviewed the 99mTc-methylene diphosphonate scintigrams in nine patients who had developed shoulder arthralgias while receiving interleukin-2 for metastatic melanoma. In eight of the patients, the scintigrams showed diffuse increased uptake of radionuclide in the shoulders. Four patients had radiographs of their shoulders, all of which were normal. Bone scintigraphy in patients receiving interleukin-2 as immunotherapy for metastatic melanoma shows increased radionuclide activity in the shoulders. This process may relate to the role of interleukin-2 as a mediator in the inflammatory response.
白细胞介素-2作为一种免疫治疗药物在某些癌症的治疗中受到广泛关注。近期有报道称严重关节痛是其一种显著的副作用，且疼痛原因不明。由于白细胞介素-2是一种免疫调节剂，我们回顾了9例在接受白细胞介素-2治疗转移性黑色素瘤期间出现肩部关节痛的患者的99mTc-亚甲基二膦酸盐闪烁扫描图像。其中8例患者的闪烁扫描图像显示肩部放射性核素摄取弥漫性增加。4例患者进行了肩部X线检查，结果均正常。接受白细胞介素-2免疫治疗转移性黑色素瘤的患者骨闪烁扫描显示肩部放射性核素活性增加。这一过程可能与白细胞介素-2作为炎症反应介质的作用有关。
