Rosenfeld S I, Mandelbaum S, Corrent G F, Pflugfelder S C, Culbertson W W
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Florida.
Am J Ophthalmol. 1990 Jan 15;109(1):17-22. doi: 10.1016/s0002-9394(14)75572-2.
We describe four patients who, using extended-wear soft contact lenses for myopia, abruptly developed ocular irritation and injection associated with elevated granular opacities initially confined to the central corneal epithelium. Cultures of the granular epithelial lesions were positive for Pseudomonas aeruginosa in all patients. Cultures of the contact lenses and lens case solutions grew Pseudomonas species and other gram-negative organisms. All patients responded to discontinuation of lens wear and frequent topical antibiotics. All recovered baseline visual acuity, and three have successfully resumed contact lens wear. These cases document that Pseudomonas keratitis may be manifested as a granular epithelial keratopathy.
我们描述了四名使用软性长戴型隐形眼镜矫正近视的患者，他们突然出现眼部刺激和充血，并伴有最初局限于中央角膜上皮的颗粒状混浊加重。所有患者颗粒状上皮病变的培养物中铜绿假单胞菌均呈阳性。隐形眼镜和镜盒溶液的培养物中生长出假单胞菌属及其他革兰氏阴性菌。所有患者在停止佩戴隐形眼镜并频繁局部使用抗生素后均有好转。所有患者均恢复了基线视力，其中三名患者已成功恢复佩戴隐形眼镜。这些病例证明，铜绿假单胞菌性角膜炎可能表现为颗粒状上皮性角膜病变。
