Department of Pathophysiology and Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou, China.
FEBS Lett. 2010 Dec 1;584(23):4711-6. doi: 10.1016/j.febslet.2010.10.057. Epub 2010 Nov 2.
p53 plays a fundamental role in the maintenance of genome integrity after DNA damage, deciding whether cells repair and live, or die. However, the rules that govern its choice are largely undiscovered. Here we show that the functional relationship between p38 and p53 is crucial in defining the cell fate after DNA damage. Upon low dose ultraviolet (UV) radiation, p38 and p53 protect the cells from apoptosis separately. Conversely, they function together to favor apoptosis upon high dose UV exposure. Taken together, a UV-induced, dose-dependent interaction between p38 and p53 acts as a switch to determine cell fate.
p53 在 DNA 损伤后维持基因组完整性方面起着至关重要的作用，决定着细胞是修复并存活，还是死亡。然而，决定其选择的规则在很大程度上尚未被发现。在这里，我们表明 p38 和 p53 之间的功能关系对于 DNA 损伤后细胞命运的定义至关重要。在低剂量紫外线 (UV) 辐射下，p38 和 p53 分别保护细胞免受凋亡。相反，它们在高剂量 UV 暴露下共同作用以促进凋亡。总之，UV 诱导的 p38 和 p53 之间的剂量依赖性相互作用充当决定细胞命运的开关。
