对照组和精神分裂症患者大脑基底神经节中的G蛋白（Gi、Go）
G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain.
作者信息
Okada F, Crow T J, Roberts G W
机构信息
Health Administration Center, Hokkaido University, Sapporo, Japan.
出版信息
J Neural Transm Gen Sect. 1990;79(3):227-34. doi: 10.1007/BF01245133.
We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.
我们利用百日咳毒素催化的ADP核糖基化反应，检测了正常人和精神分裂症患者大脑纹状体中Gi（抑制性G蛋白）或Go（一种功能未知的类似G蛋白）的存在情况。精神分裂症患者左半球壳核中Gi/Go的水平显著降低了42%；尾状核头部和苍白球的水平未发生变化。Gi或Go的减少可能是精神分裂症患者大脑中多巴胺功能增强的基础。
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