Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.
Chest. 2010 Nov;138(5):1202-12. doi: 10.1378/chest.10-0196.
Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of antiinflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed over the last decade to assess the usefulness of macrolides in other inflammatory airways diseases, such as cystic fibrosis, asthma, COPD, and bronchiolitis obliterans syndrome. This review summarizes the immunomodulatory properties of macrolides and the results of these recent studies demonstrating their potential for being disease-modifying agents.
大环内酯类抗生素红霉素的长期治疗被证明可以改变弥漫性泛细支气管炎的临床过程，这一发现始于 20 世纪 80 年代末。从那时起，人们发现除了具有抗菌作用外，大环内酯类药物还具有许多抗炎特性。这些观察结果为过去十年进行的许多研究提供了依据，这些研究评估了大环内酯类药物在其他炎症性气道疾病（如囊性纤维化、哮喘、COPD 和闭塞性细支气管炎综合征）中的用途。这篇综述总结了大环内酯类药物的免疫调节特性以及这些最近的研究结果，这些研究结果表明它们具有作为疾病修饰剂的潜力。
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