哮喘患儿的“健康”子女对乙酰甲胆碱的支气管反应。色甘酸钠治疗的效果。

Bronchial response to methacholine in "healthy" children of asthmatic parents. Effect of treatment with cromolyn sodium.

作者信息

Bruderman I, Cohen R, Schachter J

机构信息

Chest Department, Sapir Medical Center, Meir General Hospital, Kefar Sava, Israel.

出版信息

Chest. 1990 Feb;97(2):285-7. doi: 10.1378/chest.97.2.285.

DOI:10.1378/chest.97.2.285

PMID:2105190

Abstract

Cumulative dose response curves to inhaled methacholine were established in 24 "healthy" children of asthmatic parents and 7 healthy children of healthy parents. Atopic children of asthmatic parents demonstrated higher bronchial hyperreactivity (BHR) than nonatopic children. The BHR was about ten times less than in the atopic parents of asthmatic children, indicating marked increase in BHR with age in atopic members of asthmatic families. Six weeks of treatment with cromolyn sodium (disodium cromoglycate) decreased BHR significantly (p less than 0.05) in eight atopic children, while no change occurred in BHR in five nonatopic children.

摘要

对24名父母患有哮喘的“健康”儿童和7名父母健康的健康儿童建立了吸入乙酰甲胆碱的累积剂量反应曲线。父母患有哮喘的特应性儿童表现出比非特应性儿童更高的支气管高反应性（BHR）。BHR比哮喘儿童的特应性父母低约10倍，这表明哮喘家族中的特应性成员的BHR随年龄显著增加。用色甘酸钠（色甘酸二钠）治疗六周后，8名特应性儿童的BHR显著降低（p<0.05），而5名非特应性儿童的BHR没有变化。