School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, People's Republic of China.
J Biomed Mater Res B Appl Biomater. 2011 Jan;96(1):101-9. doi: 10.1002/jbm.b.31744.
Magnesium alloys may potentially be applied as biodegradable metallic materials in cardiovascular stent. However, the high corrosion rate hinders its clinical application. In this study, a new approach was adopted to control the corrosion rate by fabricating a biocompatible micro-arc oxidation/poly-L-lactic acid (MAO/PLLA) composite coating on the magnesium alloy WE42 substrate and the biocompatibility of the modified samples was investigated. The scanning electronic microscope (SEM) images were used to demonstrate the morphology of the samples before and after being submerged in hanks solution for 4 weeks. The degradation was evaluated through the magnesium ions release rate and electrochemical impedance spectroscopy (EIS) test. The biocompatibility of the samples was demonstrated by coagulation time and hemolysis behavior. The result shows that the poly-L-lactic acid (PLLA) effectively improved the corrosion resistance by sealing the microcracks and microholes on the surface of the MAO coating. The modified samples had good compatibility.
镁合金可能有潜力作为可生物降解的金属材料应用于心血管支架。然而，高腐蚀速率阻碍了其临床应用。在这项研究中，采用了一种新的方法，通过在 WE42 镁合金基底上制备生物相容性的微弧氧化/聚-L-乳酸（MAO/PLLA）复合涂层来控制腐蚀速率，并对改性样品的生物相容性进行了研究。扫描电子显微镜（SEM）图像用于展示浸泡在 Hank's 溶液中 4 周前后样品的形貌。通过镁离子释放率和电化学阻抗谱（EIS）测试评估降解情况。通过凝血时间和溶血行为来证明样品的生物相容性。结果表明，聚-L-乳酸（PLLA）通过密封 MAO 涂层表面的微裂纹和微孔，有效地提高了耐腐蚀性。改性后的样品具有良好的相容性。
