心血管支架用镁合金涂层的研究进展——综述

Advances in coatings on magnesium alloys for cardiovascular stents - A review.

作者信息

Zhang Zhao-Qi, Yang Yong-Xin, Li Jing-An, Zeng Rong-Chang, Guan Shao-Kang

机构信息

School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.

Corrosion Laboratory for Light Metals, College of Material Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.

出版信息

Bioact Mater. 2021 May 23;6(12):4729-4757. doi: 10.1016/j.bioactmat.2021.04.044. eCollection 2021 Dec.

Abstract

Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

摘要

镁(Mg)及其合金作为潜在的可生物降解材料,因其合适的力学性能和生物相容性,在心血管支架领域受到广泛关注。然而,植入的镁合金支架由于其耐腐蚀性差和内皮化不足而导致血栓形成、炎症和再狭窄的发生,限制了它们预期的临床应用。众多表面处理策略主要致力于对镁合金进行改性,以抑制其降解速率并赋予其生物功能。本综述重点突出并总结了过去十年中镁合金心血管支架功能化涂层的最新研究进展,涉及金属氧化物、金属氢氧化物、无机非金属、聚合物及其复合涂层的制备策略;以及这些策略在调节降解行为和生物功能方面的性能。还简要讨论了潜在的研究方向,以帮助指导生物功能化策略并激发进一步的创新。希望本综述能够为心血管镁基支架的表面改性提供帮助,并推动这一新兴研究领域的未来发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eca/8166647/6607e0e99a92/ga1.jpg

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