Institut für Neuroanatomie, Heinrich-Heine-Universität, Moorenstrasse 5, D-40225 Düisseldorf, Germany.
Cell Tissue Res. 1994 May;276(2):333-45. doi: 10.1007/BF00306118.
In this study, we describe the distribution of high affinity binding sites for 1,25(OH)₂-vitamin D₃(1,25-D₃) in the zebra finch (Taeniopygia guttata). Four hours following the injection of tritiated 1,25-D₃, binding of the steroid hormone was found primarily in the cell nuclei ofa variety of different organs. Neurons in numerous discrete regions of the forebrain were labeled. These forebrain regions included the nucleus accumbens, nucleus dorsomedialis posterior thalami, lobus parolfactorius,nucleus septalis lateralis and medialis, nucleus septalis,lamina medullaris dorsalis, nucleus striae terminalis,palaeostriatum augmentatum, and stratum griseum. The choroid plexuses, however, remained clear. Labeled cells were seen in several organs of the alimentary canal, in both the exocrine and the endocrine pancreas, in the proximal tubules of the kidney, in the spleen, in the bursa of Fabricius, and in the heart. The basal cells of the uropygial gland were also labeled. No specific retention was evident in the gonads of either sex. Vitamin D is thus bound by cells in systems with widely different functions. Since several of the labeled tissues are not primarily involved in calcium homeostasis, the data support the concept that vitamin D-soltriol is a steroid hormone that acts as a seasonal neuroendocrine regulator regulator and somatotrophic modulator.
在这项研究中，我们描述了高亲和力结合位点在斑马雀（Taeniopygia guttata）中 1,25(OH)₂-维生素 D₃（1,25-D₃）的分布。在注射氚标记的 1,25-D₃ 后的 4 小时，发现甾体激素的结合主要存在于各种不同器官的细胞核中。许多离散的前脑区域的神经元被标记。这些前脑区域包括伏隔核、丘脑背内侧核、外侧和内侧隔核、隔核、背侧髓质层、终纹核、古纹状体增加区和灰色层。然而，脉络丛仍然清晰。在消化道的几个器官、外分泌和内分泌胰腺、肾脏的近端小管、脾脏、法氏囊和心脏中都可以看到标记的细胞。尾脂腺的基底细胞也被标记。在两性性腺中都没有明显的特异性保留。因此，维生素 D 被具有广泛不同功能的系统中的细胞所结合。由于几个标记的组织主要不参与钙稳态，这些数据支持维生素 D-三醇是一种甾体激素，作为一种季节性神经内分泌调节剂和生长激素调节剂的概念。
