Schleicher G, Bartke A, Bidmon H J, Stumpf W E
Universität (GHS) Essen, Abteilung für Pädiatrische Endokrinologie, Zentrum für Kinder- und Jugendmedizin, Germany.
J Steroid Biochem Mol Biol. 1993 Sep;46(3):331-5. doi: 10.1016/0960-0760(93)90222-i.
Using autoradiography, binding sites for 1,25(OH)2 vitamin D3 are found in certain genital organs of male Siberian hamsters (Phodopus sungorus), in particular in basal epithelial cells and fibroblasts of the lamina propria of prostate glands. Scattered labeled cells are also present in the epithelium of coagulation and urethral glands. In contrast to the findings in mice, under the conditions of the experiment, 1,25(OH)2 vitamin D3 binding sites are not recognizable in other accessory sex glands and gonads. The frequency of basal epithelial cells with [3H]1,25(OH)2 vitamin D3 nuclear binding is higher in regressed dorsal prostate glands of animals living in short photoperiods. The data suggest that 1,25(OH)2 vitamin D3 may promote proliferation and differentiation in basal epithelial cells, modulated by the seasonal and functional status of the animal.
利用放射自显影技术，在雄性西伯利亚仓鼠（Phodopus sungorus）的某些生殖器官中发现了1,25(OH)₂维生素D₃的结合位点，特别是在前列腺固有层的基底上皮细胞和成纤维细胞中。在凝固腺和尿道腺的上皮中也存在散在的标记细胞。与小鼠的研究结果相反，在本实验条件下，在其他附属性腺和性腺中未发现1,25(OH)₂维生素D₃结合位点。生活在短光照周期的动物，其退化的背侧前列腺中具有[³H]1,25(OH)₂维生素D₃核结合的基底上皮细胞频率更高。数据表明，1,25(OH)₂维生素D₃可能促进基底上皮细胞的增殖和分化，这受动物的季节和功能状态调节。
